动脉粥样硬化中血管生成和炎症的影像学进展。
Advances in imaging angiogenesis and inflammation in atherosclerosis.
机构信息
Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.
出版信息
Thromb Haemost. 2011 May;105(5):820-7. doi: 10.1160/TH10-08-0562. Epub 2011 Feb 18.
Abstract
Advances in imaging technology have provided powerful tools for dissecting the angiogenic and inflammatory aspects of atherosclerosis. Improved technology along with multi-modal approaches has expanded the utilisation of imaging. Recent advances provide the ability to better define structure and development of angiogenic vessels, identify relationships between inflammatory mediators and the vessel wall, validate biological effects of anti-inflammatory and anti-angiogenic drugs, delivery and/or targeting specific molecules to inflammatory regions of atherosclerotic plaques.
摘要
成像技术的进步为剖析动脉粥样硬化的血管生成和炎症方面提供了强大的工具。随着多模态方法的改进，成像的应用得到了扩展。最近的进展使我们能够更好地定义血管生成血管的结构和发育，识别炎症介质与血管壁之间的关系，验证抗炎和抗血管生成药物的生物学效应，以及将特定分子递送至或靶向动脉粥样硬化斑块的炎症区域。
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