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定量 CT 成像技术研究载脂蛋白 E 基因敲除/低密度脂蛋白受体基因敲除双基因敲除小鼠主动脉中血管周细胞的时空分布模式。

Quantitative CT imaging of the spatio-temporal distribution patterns of vasa vasorum in aortas of apoE-/-/LDL-/- double knockout mice.

机构信息

Department of Radiology, University of Giessen, Germany.

出版信息

Atherosclerosis. 2010 Oct;212(2):444-50. doi: 10.1016/j.atherosclerosis.2010.07.010. Epub 2010 Jul 17.

Abstract

OBJECTIVE

To investigate the distribution of vasa vasorum (VV) relative to advanced atherosclerotic lesions (calcified, fibrotic or hemorrhaged) along the aortic wall of apoE-/-/LDL-/- mice at the age of 25 and 80 weeks using high-resolution nano-CT.

METHODS

Aortas from male apoE-/-/LDL-/- mice at the age of 25 weeks (n=4) and 80 weeks (n=7) were infused in situ with contrast agent and harvested for scanning with nano-CT. The spatial distribution of vasa vasorum [number and area/cross-section (mm2)] was compared to aortic luminal cross-sectional area and plaque cross-sectional area in the ascending aorta, aortic arch and descending aorta. Results were complemented with co-localized histology.

RESULTS

The number and total luminal cross-sectional area of VV showed a significant decrease in the ascending aorta and aortic arch from 25 to 80 weeks but not in the descending aorta. The number and cross-sectional area of VV showed significant local differences depending on whether it was near a fibrotic, and hemorrhaged or calcified plaque in animals at the age of 80 weeks. Area of VV progressively increased along the aorta from least in the ascending aorta<aortic arch<descending aorta in animals at the age of 80 weeks and is inverse in animals aged 25 weeks.

CONCLUSION

Atherosclerotic lesion type is correlated to the number and cross-sectional area of VV in different aortic segments in apoE-/-/LDL-/- mice. The chronological development of VV along the aorta proceeds distally from the ascending aorta and aortic arch.

摘要

目的

使用高分辨率纳米 CT 研究 apoE-/-/LDL-/- 小鼠 25 周和 80 周时主动脉壁中 vasa vasorum(VV)相对于晚期动脉粥样硬化病变(钙化、纤维化或出血)的分布。

方法

对 25 周龄(n=4)和 80 周龄(n=7)雄性 apoE-/-/LDL-/- 小鼠的主动脉进行原位对比剂灌注,并进行纳米 CT 扫描。将 vasa vasorum 的空间分布[数量和面积/横截面(mm2)]与升主动脉、主动脉弓和降主动脉的管腔横截面面积和斑块横截面面积进行比较。结果辅以共定位组织学。

结果

从 25 周到 80 周,升主动脉和主动脉弓的 VV 数量和总管腔横截面面积显著减少,但降主动脉没有。80 周龄动物中,VV 的数量和横截面积根据其是否靠近纤维化、出血或钙化斑块而存在显著的局部差异。80 周龄动物中,VV 的面积沿主动脉从升主动脉<主动脉弓<降主动脉逐渐增加,而 25 周龄动物则相反。

结论

在 apoE-/-/LDL-/- 小鼠的不同主动脉节段中,动脉粥样硬化病变类型与 VV 的数量和横截面积相关。VV 沿主动脉的时间发展从升主动脉和主动脉弓向远端进行。

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