Gutiérrez J, García H, Osorio G, Vacarezza R, Cao C
Rev Med Chil. 1990 Apr;118(4):473-80.
After a follow up of 22 months we report results of treatment on 44 patients (22 males), aged 16 to 63 years, with acute non lymphoblastic leukemia. Complete remission was obtained in 22 patients. This was significantly more frequent in patients under 40 years of age with white cell counts under 35,000 and without metabolic complications nor disseminated intravascular coagulation before treatment. Delaying chemotherapy for 5 days after diagnosis was also associated to a better prognosis. Overall actuarial survival rate was 37% at 15 months, 55% for those experiencing a first remission. A total of 25 patients [corrected] have died, 15 during induction of therapy, 7 after complete remission and 3 after failure of induction. Infections are the main cause of death during induction, with a high lethality for sepsis (33%) and pneumonia (40%).
在进行了22个月的随访后，我们报告了对44例年龄在16至63岁之间的急性非淋巴细胞白血病患者（22例男性）的治疗结果。22例患者获得完全缓解。在40岁以下、白细胞计数低于35,000且治疗前无代谢并发症及弥散性血管内凝血的患者中，完全缓解更为常见。诊断后延迟5天进行化疗也与较好的预后相关。15个月时的总体精算生存率为37%，首次缓解者为55%。共有25例患者死亡，15例死于诱导治疗期间，7例死于完全缓解后，3例死于诱导失败后。感染是诱导治疗期间的主要死亡原因，败血症（33%）和肺炎（40%）的致死率很高。
