血管紧张素肽的放射性标记
Radiolabeling of Angiotensin peptides.
作者信息
Speth R C, Harding J W
机构信息
Department of VCAPP, Washington State University, Pullman, WA.
出版信息
Methods Mol Med. 2001;51:275-95. doi: 10.1385/1-59259-087-X:275.
The use of radioiodinated angiotensins has contributed greatly to our knowledge of the renin-angiotensin system (RAS). This chapter provides brief descriptions of the application of radioiodinated angiotensins and other radioiodinated compounds to study the RAS and the issues that must be considered when using radioiodinated angiotensins. In addition, this chapter provides a detailed description of a method for the preparation and purification of both iodine(125) ((125)I) and iodine(127) ((127)I)-labeled angiotensin-related ligands.
放射性碘化血管紧张素的应用极大地增进了我们对肾素-血管紧张素系统（RAS）的了解。本章简要介绍了放射性碘化血管紧张素及其他放射性碘化化合物在研究RAS中的应用，以及使用放射性碘化血管紧张素时必须考虑的问题。此外，本章还详细描述了一种制备和纯化碘（125）（125I）和碘（127）（127I）标记的血管紧张素相关配体的方法。
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