Villa A, Guerrero S, Cisternas P, Mönckeberg F
Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile, Santiago.
Arch Latinoam Nutr. 1990 Jun;40(2):197-208.
In order to evaluate the efficacy of fluoridated milk as a cariostatic nutritional product, the biological and technical possibilities of adding fluoride (F) as monofluorophosphate (MFP) to milk were studied, together with a preliminary cost estimation for this procedure. F ingestion by preschool children pertaining to the low and medium-low levels of population was estimated through polls and chemical analyses. The values of F ingestion obtained were in the range of 0.15-0.30 mg/day. The bioavailability of F in those dietary elements which have the highest F concentration was determined. Taking a value of 1.00 for F absorption from sodium fluoride (NaF) in water, relative values of 0.58 and 0.32 were obtained for tea ingestion on a fasting stomach, and together with solid food, respectively. The corresponding value for fish was 0.34. Through another bioavailability experiment it was shown that the absorption of F (from MFP) in milk, is as high as that of F (from NaF) in water. By means of a comparative cost estimation study, it was found that, for the Chilean situation, milk fluoridation is, at least, 1,000 times more economic than water fluoridation. It is concluded that milk fluoridation is an economical and viable alternative for some less developed countries.
为评估氟化牛奶作为一种防龋营养产品的功效，研究了向牛奶中添加氟化物（F）作为单氟磷酸酯（MFP）的生物学和技术可能性，并对该过程进行了初步成本估算。通过民意调查和化学分析估算了中低人群学龄前儿童的氟摄入量。获得的氟摄入量值在0.15 - 0.30毫克/天范围内。测定了那些氟浓度最高的膳食元素中氟的生物利用度。以水中氟化钠（NaF）的氟吸收率为1.00，空腹饮茶和与固体食物一起饮茶时，氟的相对吸收率分别为0.58和0.32。鱼的相应值为0.34。通过另一项生物利用度实验表明，牛奶中（来自MFP）氟的吸收率与水中（来自NaF）氟的吸收率一样高。通过比较成本估算研究发现，就智利的情况而言，牛奶氟化至少比水氟化经济1000倍。得出的结论是，对于一些欠发达国家来说，牛奶氟化是一种经济可行的选择。
