Key Laboratory of Cluster Science of Ministry of Education, Department of chemistry, School of Science, Beijing Institute of Technology, Beijing 100081, People's Republic of China.
J Fluoresc. 2011 Jul;21(4):1343-8. doi: 10.1007/s10895-010-0820-0. Epub 2011 Feb 18.
A disulfide linked naphthalimide dimer probe was designed for mercury ion (Hg(2+)) recognition in this work. The recognition was based on the strong affinity of mercury for sulfur. The experimental results revealed that the probe exhibited high selectivity and sensitivity toward Hg(2+) in comparison to other metal ions via a turn-on and reversible response to Hg(2+) in neutral buffer solution. More importantly, the probe demonstrated a linear response for Hg(2+) over a concentration range from 0 to 150 μM with a detection limit of 0.38 μM, which is just the limit of the safe concentration for humans. Upon addition of 150 μM Hg(2+), the enhancement of fluorescence reached a maximum (∼7-fold). The performances of the probe indicated that it could meet the selectivity requirements for biomedical and environmental application and also was sensitive enough to detect Hg(2+) in environmental and biological samples.
在这项工作中，设计了一种二硫键连接的萘酰亚胺二聚体探针用于汞离子（Hg(2+)）的识别。这种识别是基于汞与硫的强亲和力。实验结果表明，与其他金属离子相比，探针在中性缓冲溶液中对 Hg(2+)具有高选择性和灵敏度，通过对 Hg(2+)的开-关和可逆响应。更重要的是，探针在 0 至 150 μM 的浓度范围内对 Hg(2+)表现出线性响应，检测限为 0.38 μM，这正好是人类安全浓度的极限。加入 150 μM Hg(2+)后，荧光增强达到最大值（约 7 倍）。探针的性能表明，它可以满足生物医学和环境应用的选择性要求，并且对环境和生物样品中的 Hg(2+)的检测也足够灵敏。
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