一种高选择性的 1,4-二硫苏糖醇（DTT）比率荧光探针。
A highly selective ratiometric fluorescent probe for 1,4-dithiothreitol (DTT) detection.
机构信息
Department of Chemistry, School of Science, Beijing Institute of Technology, Beijing 100081, P. R. China.
出版信息
Org Biomol Chem. 2010 Apr 7;8(7):1650-4. doi: 10.1039/b923754b. Epub 2010 Feb 3.
DOI:10.1039/b923754b
PMID:20237677
Abstract
A highly selective ratiometric fluorescent probe, which contains an aminonaphthalimide fluorophore and a self-immolative spacer for 1,4-dithiothreitol (DTT) detection was designed and synthesized. The probe displays a 66 nm red-shift of fluorescence emission and the color changes from colorless to jade-green upon reaction with DTT. These properties are mechanistically ascribed to the strong reducing capability of DTT.
摘要
一种高选择性的比率荧光探针，它包含一个氨萘酰亚胺荧光团和一个自我牺牲间隔物，用于 1,4-二硫苏糖醇（DTT）检测的设计和合成。探针显示出 66nm 的荧光发射红移，并且在与 DTT 反应时颜色从无色变为玉绿色。这些性质在机制上归因于 DTT 的强还原能力。
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