Ceyssens Sarah, Stroobants Sigrid
Department of Nuclear Medicine, Antwerp University Hospital, Edegem, Belgium.
Methods Mol Biol. 2011;727:191-203. doi: 10.1007/978-1-61779-062-1_11.
Sarcomas are a diverse group of malignancies originating in the connective tissue. The approach of a patient with a mass suspect for sarcoma starts with performing a biopsy to obtain tissue for evaluation by pathology. The main role of the current imaging modalities, in general, is to recognize patients with typically benign disease, in whom further invasive staging can be omitted, and select patients with a suspected malignancy, who should be referred for biopsy. Since soft tissue sarcoma tends to be large and heterogeneous, there is growing interest in using imaging modalities to guide these biopsies. Together with pathology, imaging modalities are the basis for accurate staging, evaluation of locoregional extent of the primary lesion, screening for occult metastases, evaluation of response to cancer treatment, and the detection of tumor recurrence. In this chapter, an overview is given of the use of 18F-FDG PET in these settings, its strengths as well as its limitations.
肉瘤是起源于结缔组织的一组多样化恶性肿瘤。对于疑似肉瘤的肿块患者，其诊疗方法首先是进行活检以获取组织供病理评估。一般来说，当前成像模态的主要作用是识别那些通常为良性疾病的患者，这类患者可省略进一步的侵入性分期检查，同时筛选出疑似恶性肿瘤的患者，这些患者应转诊进行活检。由于软组织肉瘤往往体积较大且具有异质性，因此使用成像模态来指导这些活检的兴趣日益浓厚。成像模态与病理学一起，是准确分期、评估原发病变的局部区域范围、筛查隐匿性转移、评估癌症治疗反应以及检测肿瘤复发的基础。在本章中，将概述18F-FDG PET在这些情况下的应用、其优势以及局限性。
