Yener Oktay, Aksoy Fikret, Demır Mustafa, Özçelık Alp, Erengül Canan
Department of Surgery, Göztepe Training and Research Hospital, İstanbul.
Turk J Gastroenterol. 2010 Dec;21(4):411-5. doi: 10.4318/tjg.2010.0128.
BACKGROUND/AIMS: We aimed to evaluate the prevalence of non-alcoholic steatohepatitis and metabolic syndrome in patients with symptomatic gallstones undergoing laparoscopic or open cholecystectomy.
A study of 95 patients was performed. Simultaneous liver biopsies were taken during cholecystectomy between 2006 and 2007. There were no postoperative complications. Patients with significant alcohol intake, hepatitis B or C (virus-positive), autoimmune diseases, and Wilson's disease were excluded. Demographics, liver function tests, lipid profile, and ultrasound findings of patients with and without non-alcoholic steatohepatitis were compared.
A total of 95 patients completed the study. The mean age was 52.15 years, and 29 patients were male and 66 female. Fifty-two patients (55%) had biopsies compatible with non-alcoholic steatohepatitis.
Fifty-five percent of patients with gallbladder stones had associated non-alcoholic steatohepatitis. Awareness of this association may result in an earlier diagnosis. The high prevalence of non-alcoholic steatohepatitis in patients with gallbladder stone may justify routine liver biopsy during cholecystectomy to establish the diagnosis and stage and possibly direct therapy.
背景/目的：我们旨在评估接受腹腔镜或开腹胆囊切除术的有症状胆结石患者中非酒精性脂肪性肝炎和代谢综合征的患病率。
对95例患者进行了一项研究。在2006年至2007年胆囊切除术中同时进行肝脏活检。无术后并发症。排除大量饮酒、乙型或丙型肝炎（病毒阳性）、自身免疫性疾病和威尔逊病患者。比较有无非酒精性脂肪性肝炎患者的人口统计学、肝功能检查、血脂谱和超声检查结果。
共有95例患者完成研究。平均年龄为52.15岁，男性29例，女性66例。52例（55%）患者的活检结果符合非酒精性脂肪性肝炎。
55%的胆结石患者伴有非酒精性脂肪性肝炎。认识到这种关联可能会导致更早的诊断。胆结石患者中非酒精性脂肪性肝炎的高患病率可能使胆囊切除术中常规肝脏活检成为必要，以确立诊断和分期，并可能指导治疗。
