Owen J, Hunter-Laszlo M, Williams J K, Adams M
Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
Blood Coagul Fibrinolysis. 1990 Oct;1(4-5):505-7. doi: 10.1097/00001721-199010000-00026.
In this paper we address the question of whether balloon angioplasty induces thrombin action. In the studies reported here we measured fibrinopeptide A levels in a group of atherosclerotic monkeys undergoing coronary angioplasty. A blood collection catheter was introduced into the inferior vena cava through a femoral vein, and the angioplasty catheter introduced via the femoral artery. Heparin was administered immediately after insertion of the arterial catheter. Serial blood samples were collected for 20 min before angioplasty and for 10 min after angioplasty. Baseline levels of FpA were high, presumably in response to the trauma of introducing the catheters. After heparin administration the FpA concentration declined with a half-time of 1.1 min. In response to balloon inflation there was a clear increase in the concentration of FpA, despite the presence of a therapeutic concentration of heparin. The magnitude of the FpA rise was markedly different between animals, but was evident in the aggregate data after subtraction of background levels of FpA. By integration of the plasma FpA concentration curve, the amount of fibrinogen converted to fibrin in response to angioplasty was calculated to be approximately 0.4 mg/animal. We conclude that angioplasty induces significant activation of the coagulation system.
在本文中，我们探讨了球囊血管成形术是否会引发凝血酶作用的问题。在此处报道的研究中，我们测量了一组接受冠状动脉血管成形术的动脉粥样硬化猴子的纤维蛋白肽A水平。通过股静脉将采血导管插入下腔静脉，并经股动脉插入血管成形术导管。在插入动脉导管后立即给予肝素。在血管成形术前20分钟和血管成形术后10分钟采集系列血样。FpA的基线水平较高，推测是对插入导管的创伤的反应。给予肝素后，FpA浓度以1.1分钟的半衰期下降。尽管存在治疗浓度的肝素，但在球囊扩张后，FpA的浓度仍明显升高。不同动物之间FpA升高的幅度明显不同，但在减去FpA的背景水平后的总体数据中很明显。通过整合血浆FpA浓度曲线，计算出因血管成形术而转化为纤维蛋白的纤维蛋白原量约为0.4mg/只动物。我们得出结论，血管成形术会引发凝血系统的显著激活。
