Molecular Inflammation Research Center for Aging Intervention, College of Pharmacy, Pusan National University, San 30, Jangjeon-dong, Geumjeong-gu, Busan, 609-735, Republic of Korea.
J Med Food. 2011 Mar;14(3):232-9. doi: 10.1089/jmf.2010.1039.
Soybean has many compounds with a variety of biological properties that potentially benefit human health; among them, isoflavones have inhibitory effects on lipid oxidation in adipose tissue. In this study, we examined two Korean traditional fermented soybean products--doenjang (DNJ) and cheonggukjang (CGJ)--for their ability to suppress redox-sensitive nuclear factor κB (NF-κB) activation in the kidney of rats fed a high-fat diet. Sprague-Dawley rats, 4 weeks old, were fed soybean, DNJ, or CGJ (1 g/kg/day) with a 20% fat diet for 6 weeks. Body weight and food intake were carefully monitored. NF-κB-related activities of genes for inflammatory proteins, such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and vascular cell adhesion molecule-1 (VCAM-1), were determined. The soybean products exhibited antioxidative action by maintaining redox regulation, suppressing NF-κB activation, and modulating the expression of genes for NF-κB-induced inflammatory proteins such as COX-2, iNOS, and VCAM-1. Based on these results, we conclude that Korean traditional soybean fermented products, especially CGJ, suppress the generation of reactive species, NF-κB activity, and NF-κB-related inflammatory genes.
大豆含有许多具有多种生物特性的化合物，这些化合物可能对人类健康有益；其中，异黄酮对脂肪组织中的脂质氧化具有抑制作用。在这项研究中，我们研究了两种韩国传统发酵大豆制品——味噌（DNJ）和清曲酱（CGJ），以研究它们抑制高脂肪饮食喂养大鼠肾脏中氧化还原敏感核因子 κB（NF-κB）激活的能力。4 周龄 Sprague-Dawley 大鼠用含有 20%脂肪的饮食喂养大豆、DNJ 或 CGJ（1 g/kg/天）6 周。仔细监测体重和食物摄入量。测定了与炎症蛋白相关的基因（如诱导型一氧化氮合酶（iNOS）、环氧化酶-2（COX-2）和血管细胞黏附分子-1（VCAM-1））的 NF-κB 相关活性。大豆制品通过维持氧化还原调节、抑制 NF-κB 激活以及调节 NF-κB 诱导的炎症蛋白（如 COX-2、iNOS 和 VCAM-1）的基因表达来发挥抗氧化作用。基于这些结果，我们得出结论，韩国传统大豆发酵产品，特别是 CGJ，可抑制活性物质、NF-κB 活性和 NF-κB 相关炎症基因的产生。
