Department of Food Science and Nutrition, University of Ulsan, Nam-ku, Ulsan, Republic of Korea.
J Med Food. 2011 Mar;14(3):310-5. doi: 10.1089/jmf.2010.1367.
Metabolic dysregulation (e.g., hyperglycemia, hyperinsulinemia, hyperlipidemia, etc.) is a hallmark of obesity-related diseases such as insulin resistance, type 2 diabetes, and fatty liver disease. In this study, we assessed whether dietary capsaicin attenuated the metabolic dysregulation in genetically obese diabetic KKAy mice, which have severe diabetic phenotypes. Male KKAy mice fed a high-fat diet for 2 weeks received a 0.015% capsaicin supplement for a further 3 weeks and were compared with nonsupplemented controls. Dietary capsaicin markedly decreased fasting glucose/insulin and triglyceride levels in the plasma and/or liver, as well as expression of inflammatory adipocytokine genes (e.g., monocyte chemoattractant protein-1 and interleukin-6) and macrophage infiltration. At the same time expression of the adiponectin gene/protein and its receptor, AdipoR2, increased in adipose tissue and/or plasma, accompanied by increased activation of hepatic AMP-activated protein kinase, a marker of fatty acid oxidation. These findings suggest that dietary capsaicin reduces metabolic dysregulation in obese/diabetic KKAy mice by enhancing expression of adiponectin and its receptor. Capsaicin may be useful as a dietary factor for reducing obesity-related metabolic dysregulation.
代谢失调（例如高血糖、高胰岛素血症、高血脂等）是肥胖相关疾病的标志，如胰岛素抵抗、2 型糖尿病和脂肪肝疾病。在这项研究中，我们评估了饮食中的辣椒素是否能减轻具有严重糖尿病表型的遗传性肥胖糖尿病 KKAy 小鼠的代谢失调。喂食高脂肪饮食 2 周的雄性 KKAy 小鼠进一步接受 0.015%辣椒素补充剂 3 周，并与未补充对照组进行比较。饮食中的辣椒素显著降低了血浆和/或肝脏中的空腹血糖/胰岛素和甘油三酯水平，以及炎症脂肪细胞因子基因（如单核细胞趋化蛋白-1 和白细胞介素-6）和巨噬细胞浸润的表达。同时，脂肪组织和/或血浆中脂联素基因/蛋白及其受体 AdipoR2 的表达增加，伴随着肝 AMP 激活蛋白激酶的活性增加，这是脂肪酸氧化的标志物。这些发现表明，饮食中的辣椒素通过增强脂联素及其受体的表达来减轻肥胖/糖尿病 KKAy 小鼠的代谢失调。辣椒素可能是一种有用的饮食因子，可减少肥胖相关的代谢失调。
