Strauss Eric J, Fonseca Lauren E, Shah Mehul R, Yorum Thomas
Division of Sports Medicine, Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, NYU Langone Medical Center, New York, New York, USA.
Bull NYU Hosp Jt Dis. 2011;69(1):63-72.
Injuries to the articular cartilage of the knee are common. They alter the normal distribution of weightbearing forces and predispose patients to the development of degenerative joint disease. The management of focal chondral lesions continues to be problematic for the treating orthopaedic surgeon. Although many treatment options are currently available, none fulfill the criteria for an ideal repair solution: a hyaline repair tissue that completely fills the defect and integrates well with the surrounding normal cartilage. Autologous chondrocyte implantation (ACI) is a relatively new cell-based treatment method for full-thickness cartilage injuries that in recent years has increased in popularity, with early studies showing promising results. The current article reviews the nature of cartilage lesions in the knee and the treatment modalities utilized in their management, focusing on the role ACI plays in the surgical treatment of these complex injuries.
膝关节的关节软骨损伤很常见。它们改变了负重力量的正常分布，使患者易患退行性关节疾病。对于治疗骨科医生来说，局灶性软骨损伤的处理仍然存在问题。尽管目前有许多治疗选择，但没有一种能满足理想修复方案的标准：即一种能完全填充缺损并与周围正常软骨良好整合的透明软骨修复组织。自体软骨细胞植入（ACI）是一种相对较新的针对全层软骨损伤的基于细胞的治疗方法，近年来越来越受欢迎，早期研究显示出有希望的结果。本文回顾了膝关节软骨损伤的性质以及在其处理中使用的治疗方式，重点关注ACI在这些复杂损伤的手术治疗中所起的作用。
