Han J, Jiao L, Lu Y, Sun Z, Gu Q M, Scanlon K J
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
In Vivo. 1990 May-Jun;4(3):153-60.
In this review, a retinoid analogue (N-4-hydroxycarbophenyl) retinamide (R11) has been evaluated for its pharmacological and clinical properties. R11 has been studied both as a cancer prevention agent, as well as, a cancer chemotherapeutic agent. R11 alone and in combination with other agents can be used for the treatment of cervical dysplasia or leukemia. This review will examine novel strategies and mechanisms of action for retinoids in the treatment and prevention of cancer.
在本综述中，已对一种类视黄醇类似物（N - 4 - 羟基羰基苯基）视黄酰胺（R11）的药理特性和临床特性进行了评估。R11已作为一种癌症预防剂以及癌症化疗剂进行了研究。R11单独使用或与其他药物联合使用可用于治疗宫颈发育异常或白血病。本综述将探讨类视黄醇在癌症治疗和预防中的新策略及作用机制。
