Goguel A F, Le Borgne F, Baude B, Canavate M L, Tlouzeau S, Derhy M L, Lespinats G
Laboratoire d'Immunobiologie, Institut de Recherches Scientifiques sur le Cancer, Villejuif, France.
In Vivo. 1990 May-Jun;4(3):185-90.
Hybridization of a poorly immunogenic tumor cell with an allogeneic cell was performed in order to improve tumor immune response; several variants derived from one hybrid tumor cell were studied. We compared the immunogenicity of these variants and their allogeneic and syngeneic class I antigen expression before and after IFN gamma treatment. Allogeneic class I antigens were weakly expressed in all variants; IFN treatment enhanced their expression similarly in both immunogenic and nonimmunogenic variants. Syngeneic class I antigen expression differed among variants: IFN treatment induced changes in their expression which corresponded to a posttranscriptional event and which could, at least partly, explain the modifications observed in their immunogenicity.
为了改善肿瘤免疫反应，将免疫原性较差的肿瘤细胞与同种异体细胞进行杂交；对源自一个杂交肿瘤细胞的几个变体进行了研究。我们比较了这些变体的免疫原性以及它们在干扰素γ处理前后的同种异体和同基因I类抗原表达。在所有变体中，同种异体I类抗原表达较弱；干扰素处理使免疫原性和非免疫原性变体中的表达均类似地增强。同基因I类抗原表达在变体间存在差异：干扰素处理诱导其表达发生变化，这与转录后事件相对应，并且至少可以部分解释在其免疫原性中观察到的改变。
