Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Mannheim, Germany.
Acta Ophthalmol. 2011 Aug;89(5):e423-7. doi: 10.1111/j.1755-3768.2011.02121.x. Epub 2011 Feb 18.
To measure the thickness of the lamina cribrosa and peripapillary sclera in monkeys with a nonglaucomatous optic nerve damage and to compare that with those of monkeys with glaucomatous optic neuropathy.
The study included 22 monkey eyes (Macaca mulatta) which had undergone a temporary experimental central retinal artery occlusion (CRAO) and seven monkey eyes in which experimental glaucoma was unilaterally produced. We measured histomorphometrically the thickness of the lamina cribrosa and peripapillary sclera.
The lamina cribrosa was significantly thicker in the CRAO group than in the glaucoma group (central region: 212 ± 46 μm versus 167 ± 17 μm; p = 0.009). The thickness of the peripapillary sclera at the optic disc border (253 ± 39 μm versus 192 ± 21 μm; p = 0.001) and outside of the optic nerve meninges (408 ± 70 μm versus 314 ± 64 μm; p = 0.006) was significantly greater in the CRAO group.
In monkey eyes with a temporary CRAO as a model for nonglaucomatous optic nerve damage, the lamina cribrosa is significantly thicker than in monkey eyes with experimental glaucomatous optic nerve damage. It may suggest that the loss of optic nerve fibres might not be the reason for the thinning of the lamina cribrosa in eyes with advanced glaucoma. The thinner peripapillary sclera in the glaucomatous eyes may suggest that the monkey sclera is more vulnerable to stretching with increased intraocular pressure than the human eye for which no glaucoma-related lengthening of the eyeball and thinning of the peripapillary sclera have been observed.
测量非青光眼性视神经损伤猴的神经纤维层和视盘周围巩膜的厚度，并与青光眼性视神经病变猴进行比较。
本研究纳入了 22 只猴眼（猕猴），这些猴眼经历了短暂的实验性中心性视网膜动脉阻塞（CRAO），以及 7 只单侧发生实验性青光眼的猴眼。我们通过组织形态计量学方法测量了神经纤维层和视盘周围巩膜的厚度。
CRAO 组的神经纤维层明显比青光眼组厚（中央区：212±46μm 比 167±17μm；p=0.009）。视盘边缘的视盘周围巩膜厚度（253±39μm 比 192±21μm；p=0.001）和视神经脑膜外的视盘周围巩膜厚度（408±70μm 比 314±64μm；p=0.006）在 CRAO 组中显著增加。
在以短暂性 CRAO 作为非青光眼性视神经损伤模型的猴眼中，神经纤维层明显比实验性青光眼性视神经损伤猴的神经纤维层厚。这可能表明，视神经纤维的丧失可能不是晚期青光眼患者神经纤维层变薄的原因。青光眼眼中较薄的视盘周围巩膜可能表明，与人类眼球相比，猴子巩膜对眼压升高引起的拉伸更为敏感，而人类眼球尚未观察到与青光眼相关的眼球延长和视盘周围巩膜变薄。
