Division of Reproductive and Perinatal Health, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Birth. 2011 Mar;38(1):10-6. doi: 10.1111/j.1523-536X.2010.00441.x. Epub 2010 Dec 23.
Preterm birth is the principal risk factor for neonatal morbidity and mortality. The objective of this study was to investigate the association between antenatal depressive symptoms and preterm birth.
The study included a national sample of 2,904 pregnant women who were recruited at their first booked visit to antenatal clinics in Sweden. Data on depressive symptoms, and sociodemographic and reproductive background were collected by questionnaires. Depressive symptoms were assessed by the Edinburgh Postnatal Depression Scale (EPDS). The average length of gestation at the time for completion of the questionnaire was 16 weeks. Data on gestational length were extracted from the Swedish Medical Birth Register. Multiple logistic regression analyses were conducted to estimate the risk of preterm birth associated with antenatal depressive symptoms.
The presence of antenatal depressive symptoms above a cutoff score of 12 or higher on the EPDS increased the risk for preterm birth (OR: 1.56; 95% CI: 1.03-2.35). Being of age 35 years and over, being a primipara, and having experienced a previous miscarriage were also shown to be significant predictors in a multivariate model.
Pregnant women reporting antenatal depressive symptoms are at elevated risk of preterm birth.
早产是新生儿发病率和死亡率的主要危险因素。本研究旨在探讨产前抑郁症状与早产之间的关系。
本研究纳入了 2904 名在瑞典产前诊所首次预约就诊的孕妇作为研究对象，采用问卷调查收集了抑郁症状以及社会人口学和生殖背景等数据。采用爱丁堡产后抑郁量表（EPDS）评估抑郁症状。完成问卷时的平均孕周为 16 周。妊娠时长数据从瑞典医疗出生登记处提取。采用多因素逻辑回归分析评估产前抑郁症状与早产风险之间的关系。
EPDS 评分高于 12 分的产前抑郁症状增加了早产风险（OR：1.56；95% CI：1.03-2.35）。年龄在 35 岁及以上、初产妇以及曾经历过流产也是多变量模型中的显著预测因素。
报告产前抑郁症状的孕妇早产风险增加。
