Ko Pamela P, Pritt Stacy L, Mundwiler Karen E, Ackley Valerie K, Matthews Ray V, Unverdorben Martin
B Braun Medical, Biological Test Center, Irvine, California, USA.
J Am Assoc Lab Anim Sci. 2011 Jan;50(1):94-7.
A 26.6-kg, intact, 9-mo-old female Göttingen minipig was presented for a coronary stent study. Angiography revealed a sinus of Valsalva aneurysm (SVA) in the aortic root that involved both the left and noncoronary sinuses of the heart. Gross histologic examination of the heart revealed 2 regions of aneurysmal formation: one at the ostium to the left main coronary artery, with aortic sinus involvement, and the other at the dorsal aspect of the aortic root involving the noncoronary aortic sinus. With no history of any infectious diseases, and the microscopic findings showing no evidence of necrosis, degeneration, or infection, confirmed that the aneurysmal-like dilation of the sinuses was most likely a congenital anomaly. This case illustrates the diagnosis and comparative findings of a rare cardiac anomaly found in only a few species to date. To our knowledge, antemortem diagnosis of unruptured SVA involving both the left and noncoronary aortic sinuses of the minipig heart has not been reported previously.
一只体重26.6千克、健康、9月龄的雌性哥廷根小型猪被送来进行冠状动脉支架研究。血管造影显示主动脉根部有一个累及心脏左窦和无冠状动脉窦的瓦氏窦瘤（SVA）。心脏的大体组织学检查发现有两个动脉瘤形成区域：一个在左主冠状动脉开口处，累及主动脉窦；另一个在主动脉根部背侧，累及无冠状动脉主动脉窦。由于没有任何传染病史，且显微镜检查结果未显示坏死、变性或感染迹象，证实这些窦的动脉瘤样扩张很可能是一种先天性异常。该病例说明了迄今为止仅在少数物种中发现的一种罕见心脏异常的诊断和比较结果。据我们所知，此前尚未报道过对小型猪心脏中累及左窦和无冠状动脉窦的未破裂SVA进行生前诊断的情况。
