Cavallo G
Institute of Microbiology, University of Turin, Italy.
G Batteriol Virol Immunol. 1990 Jan-Dec;83(1-12):156-63.
In the last fifteen years the role of cytokines in the modulation of anti-tumor responses has been extensively studied at the Institute of Microbiology of the University of Turin. In retrospect many observations appear to have been quite innovative and original. Altogether they form the steps of a consequential intellectual endeavour leading progressively towards a precise definition of the role of the lymphokines in modulating the immune response to neoplasia. Starting from the characterization of the tumor signals required for lymphokine induction, this research progressed towards the definition of the cellular, molecular and genetic mechanisms involved, and provisionally ends with the direct manipulation of lymphokine genes transfected to tumor cells.
在过去的十五年里，都灵大学微生物研究所对细胞因子在调节抗肿瘤反应中的作用进行了广泛研究。回顾过去，许多观察结果似乎都颇具创新性和独到之处。它们共同构成了一项连贯的智力探索的各个阶段，逐步朝着精确界定淋巴因子在调节对肿瘤的免疫反应中的作用迈进。这项研究从对诱导淋巴因子所需的肿瘤信号的特征描述开始，进而确定所涉及的细胞、分子和遗传机制，最后暂时以直接操纵转染到肿瘤细胞中的淋巴因子基因而告终。
