Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, United States.
Vet Parasitol. 2011 Jun 10;178(3-4):346-9. doi: 10.1016/j.vetpar.2011.01.028. Epub 2011 Jan 21.
This study evaluated the efficacy of two different doses of amprolium in goats heavily infected with pathogenic Eimeria species. Forty Boer goat kids ranging from 3 to 5 months of age with naturally occurring coccidiosis were randomly divided into 2 groups and treated orally with amprolium at doses of 10mg/kg daily for 5 days (n=20) or 50mg/kg daily for 5 days (n=20). The Eimeria oocyst per gram concentrations were significantly reduced on day 7 in the kids that received amprolium at 50mg/kg, however oocyst concentrations were not significantly reduced in goats that received the 10mg/kg dose. Out of 100 Eimeria oocysts identified from a pooled fecal sample, E. christenseni was the most frequently identified (52%) coccidial species present. The results of this trial indicate that amprolium can be an effective treatment for pathogenic Eimeria species in goat kids, however higher and extralabel doses (50mg/kg) should be used.
本研究评估了两种不同剂量安普罗在感染致病性艾美耳球虫的山羊中的疗效。将 40 只 3 至 5 月龄、自然感染球虫的布尔山羊羔羊随机分为 2 组,分别口服安普罗 10mg/kg·d,连用 5 天(n=20)或 50mg/kg·d,连用 5 天(n=20)。第 7 天,50mg/kg 组羔羊的艾美耳球虫卵囊浓度显著降低,但 10mg/kg 组的卵囊浓度没有显著降低。从混合粪便样本中鉴定出的 100 个艾美耳球虫卵囊中,E. christenseni 是最常见的(52%)球虫种。本试验结果表明,安普罗可有效治疗山羊致病性艾美耳球虫,但应使用更高和超说明书剂量(50mg/kg)。