妊娠第18至20天发育中大鼠胎儿后脑和脊髓中的血管紧张素原：一项免疫细胞化学研究。

Angiotensinogen in the developing rat fetal hindbrain and spinal cord from 18th to 20th day of gestation: an immunocytochemical study.

作者信息

Sood P P, Richoux J P, Panigel M, Bouhnik J, Wegmann R

机构信息

Department of Biosciences, Saurashtra University, Rajkot, India.

出版信息

Neuroscience. 1990;37(2):517-22. doi: 10.1016/0306-4522(90)90419-5.

DOI:10.1016/0306-4522(90)90419-5

PMID:2133356

Abstract

We have detected angiotensinogen immunoreactivity in the hindbrain and in the spinal cord of rat fetuses during the 18th to 20th day of gestation. In the 18th-day fetus, a few immunoreactive angiotensinogen cells are localized in precise brain areas. Their number sharply increase during the 19th and 20th day gestation period when there is an active cell differentiation and cell growth. These observations suggest a role of the renin-angiotensinogen system during cell growth and cell differentiation.

摘要

我们在妊娠第18至20天的大鼠胎儿的后脑和脊髓中检测到血管紧张素原免疫反应性。在第18天的胎儿中，一些免疫反应性血管紧张素原细胞位于精确的脑区。在妊娠第19天和第20天，当细胞进行活跃的分化和生长时，它们的数量急剧增加。这些观察结果表明肾素-血管紧张素原系统在细胞生长和细胞分化过程中发挥作用。