Department of Zoology, DDU Gorakhpur University, Gorakhpur 273009, India.
Tissue Cell. 2011 Apr;43(2):131-6. doi: 10.1016/j.tice.2011.01.001. Epub 2011 Feb 18.
Male Wistar rats were randomly divided into three groups--A, B and C. A dose of 5 mg and 10 mg of cadmium chloride/kg body weight/day was orally administered to groups B and C, respectively. Rats from group A served as control. Rats were sacrificed on 1st, 2nd, 4th, 6th, and 8th week after initiation of the experiment. Kidneys were removed immediately, fixed in Bouin's fixative, routinely processed and stained with hematoxylin and eosin. The present study showed that the histopathological changes were caused in kidney of rats by cadmium exposure. The changes noticed were mainly--the glomerular swelling (at initial stage), the shrinkage of glomerulus (at later stage), the tubular dilatation, hypertrophy of tubular epithelium, degeneration of glomerulus and renal tubules and deposition of eosin-positive substances in the glomerulus and renal tubules. However, lesions were depended upon the doses and duration of the treatment.
雄性 Wistar 大鼠被随机分为三组 - A、B 和 C。B 组和 C 组分别给予 5mg 和 10mg 氯化镉/公斤体重/天的剂量口服。A 组大鼠作为对照。实验开始后第 1、2、4、6 和 8 周处死大鼠。立即取出肾脏，用 Bouin 固定液固定，常规处理后用苏木精和伊红染色。本研究表明，镉暴露导致大鼠肾脏发生组织病理学变化。观察到的变化主要是 - 肾小球肿胀（初期）、肾小球缩小（后期）、肾小管扩张、肾小管上皮细胞肥大、肾小球和肾小管变性以及嗜酸性物质在肾小球和肾小管中的沉积。然而，病变取决于治疗的剂量和时间。
