Cytoarchitectural alterations in kidney of Wistar rat after oral exposure to cadmium chloride.

Male Wistar rats were randomly divided into three groups--A, B and C. A dose of 5 mg and 10 mg of cadmium chloride/kg body weight/day was orally administered to groups B and C, respectively. Rats from group A served as control. Rats were sacrificed on 1st, 2nd, 4th, 6th, and 8th week after initiation of the experiment. Kidneys were removed immediately, fixed in Bouin's fixative, routinely processed and stained with hematoxylin and eosin. The present study showed that the histopathological changes were caused in kidney of rats by cadmium exposure. The changes noticed were mainly--the glomerular swelling (at initial stage), the shrinkage of glomerulus (at later stage), the tubular dilatation, hypertrophy of tubular epithelium, degeneration of glomerulus and renal tubules and deposition of eosin-positive substances in the glomerulus and renal tubules. However, lesions were depended upon the doses and duration of the treatment.