参加 ERSPC Rotterdam 的初始前列腺特异性抗原（PSA）水平低于 3.0ng/ml 的男性的前列腺癌发病率和疾病特异性生存率。
Prostate cancer incidence and disease-specific survival of men with initial prostate-specific antigen less than 3.0 ng/ml who are participating in ERSPC Rotterdam.
机构信息
Department of Urology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands.
出版信息
Eur Urol. 2011 Apr;59(4):498-505. doi: 10.1016/j.eururo.2011.01.001. Epub 2011 Feb 18.
BACKGROUND
The European Randomised Study of Screening for Prostate Cancer (ERSPC) applies a prostate-specific antigen (PSA) cut-off value ≥3.0 ng/ml as an indication for lateralised sextant biopsy.
OBJECTIVE
To analyse the incidence and disease-specific mortality for prostate cancer (PCa) in men with an initial PSA <3.0 ng/ml.
DESIGN, SETTING AND PARTICIPANTS: From November 1993 to December 1999, a total of 42,376 men identified from population registries in the Rotterdam region (55-74 yr of age) were randomised to an intervention or control arm. A total of 19,950 men were screened during the first screening round.
INTERVENTION
A PSA <3.0 ng/ml was below the biopsy threshold. PCa cases were identified at rescreens every 4 yr or as interval cancers.
MEASUREMENTS
Distribution of incidence, aggressiveness, and disease-specific mortality of PCa per PSA range was measured. Causes of death were evaluated by an independent committee, and follow-up was complete until 31 December 2008.
RESULTS AND LIMITATIONS
From 1993 to 2008, 915 PCa cases were diagnosed in 15,758 men (5.8%) with an initial PSA <3.0 ng/ml and a median age of 62.3 yr. Median overall follow-up was 11 yr. PCa incidence increased significantly with higher initial PSA levels. Aggressive PCa (clinical stage ≥T2c, Gleason score ≥8, PSA >20 ng/ml, positive lymph nodes, or metastases at diagnosis) was detected in 66 of 733 screen-detected PCa cases (9.0%) and 72 of 182 interval-detected PCa cases (39.6%). Twenty-three PCa deaths occurred in the total population (0.15%), with an increasing risk of PCa mortality in men with higher initial PSA values.
CONCLUSIONS
The risk of PCa, aggressive PCa and PCa mortality in a screening population with initial PSA <3.0 ng/ml increases significantly with higher initial PSA levels. These results contribute to the risk stratification and individual management of men in PSA-based screening programmes.
背景
欧洲前列腺癌筛查随机研究（ERSPC）采用前列腺特异性抗原（PSA）截断值≥3.0ng/ml 作为侧向六区活检的指征。
目的
分析初始 PSA<3.0ng/ml 的男性前列腺癌（PCa）的发病率和疾病特异性死亡率。
设计、地点和参与者：1993 年 11 月至 1999 年 12 月，从鹿特丹地区的人口登记册中随机抽取 42376 名年龄在 55-74 岁的男性进入干预组或对照组。共有 19950 名男性在第一轮筛查中接受了筛查。
干预措施
PSA<3.0ng/ml 低于活检阈值。在每 4 年一次的复查中或作为间期癌发现 PCa 病例。
测量
测量每个 PSA 范围内 PCa 的发病率、侵袭性和疾病特异性死亡率分布。死因由独立委员会评估，随访至 2008 年 12 月 31 日结束。
结果和局限性
从 1993 年到 2008 年，在 15758 名初始 PSA<3.0ng/ml 的男性中诊断出 915 例 PCa（5.8%），中位年龄为 62.3 岁。中位总随访时间为 11 年。随着初始 PSA 水平的升高，PCa 的发病率显著增加。在 733 例筛查发现的 PCa 病例中，有 66 例（9.0%）为侵袭性 PCa（临床分期≥T2c、Gleason 评分≥8、PSA>20ng/ml、阳性淋巴结或诊断时转移），在 182 例间期发现的 PCa 病例中，有 72 例（39.6%）为侵袭性 PCa。在总人群中，有 23 例 PCa 死亡（0.15%），随着初始 PSA 值的升高，PCa 死亡的风险也随之增加。
结论
在初始 PSA<3.0ng/ml 的筛查人群中，PCa、侵袭性 PCa 和 PCa 死亡率的风险随着初始 PSA 水平的升高而显著增加。这些结果有助于对 PSA 为基础的筛查项目中男性进行风险分层和个体化管理。
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