Department of Dermatology, HGR 36, IMSS, Puebla, Mexico.
Autoimmun Rev. 2011 Oct;10(12):762-5. doi: 10.1016/j.autrev.2011.02.004. Epub 2011 Feb 18.
Vitiligo is a common depigmenting disorder which may have devastating psychological and social consequences and is characterized by the presence of circumscribed white macules in the skin due to the destruction of melanocytes in the epidermis. Various hypotheses have been proposed to explain the pathomechanisms involved in this disease, and studies have shown the participation of autoimmune processes in the pathogenesis of vitiligo. Cellular and humoral immunities have been implicated in the development of vitiligo and their role continues to be investigated. Peripheral blood and skin biopsies of patients with vitiligo show that T-cells, mononuclear cells, various pro-inflammatory cytokines, and auto-antibodies can damage melanocytes. Further research is required to determine whether autoimmunity is the main mechanism of vitiligo or only a consequence.
白癜风是一种常见的色素脱失性疾病，可能会产生严重的心理和社会后果，其特征是由于表皮黑素细胞的破坏，导致皮肤出现局限性的白色斑块。目前已经提出了各种假说来解释该疾病的发病机制，研究表明自身免疫过程参与了白癜风的发病。细胞免疫和体液免疫被认为与白癜风的发生有关，其作用仍在研究中。白癜风患者的外周血和皮肤活检显示，T 细胞、单核细胞、各种促炎细胞因子和自身抗体可损伤黑素细胞。需要进一步的研究来确定自身免疫是白癜风的主要机制还是仅仅是一种后果。
