Wayne State University Sleep Research Laboratory, John D. Dingell Veterans Affairs Medical Center, 4646 John R, Detroit, MI 48201, USA.
Respir Physiol Neurobiol. 2011 May 31;176(3):136-43. doi: 10.1016/j.resp.2011.02.007. Epub 2011 Feb 18.
We hypothesized that inhibition of ventilatory motor output leads to increased pharyngeal compliance during NREM sleep, independent of lung volume.
Eighteen subjects were studied using noninvasive positive pressure ventilation (NPPV) to inhibit ventilatory motor output during stable NREM sleep. Nasopharyngoscopy was used to measure the retro palatal cross-sectional area/pressure relationship (CSA/Pph) in 8 subjects. The effect of NPPV on neck circumference (NC) and end-expiratory lung volumes (EELV) was studied in 10 additional subjects using strain gauge plethysmography and respitrace, respectively.
(1) The CSA/Pph was increased during expiration under passive compared to active breathing (11.7 ± 7.1 vs. 8.5 ± 5.6mm(2)/cmH(2)O, respectively; p < 0.05) but not during inspiration. (2) NC correlated with the CSA/Pph during passive expiration (R(2) = 0.77, p < 0.05). (3) NC and EELV did not change between active and passive breaths (p = NS).
(1) Inhibiting the ventilatory motor output increases the pharyngeal compliance. (2) Increased passive expiratory pharyngeal compliance was not associated with changes in NC or EELV.
我们假设，在非快速动眼睡眠（NREM）期间，抑制通气运动输出会导致咽腔顺应性增加，而与肺容积无关。
使用无创正压通气（NPPV）抑制 18 名受试者在稳定的 NREM 睡眠期间的通气运动输出。鼻咽喉镜用于测量 8 名受试者的后咽横截面积/压力关系（CSA/Pph）。使用应变片体积描记术和 respitrace 分别在另外 10 名受试者中研究 NPPV 对颈围（NC）和呼气末肺容积（EELV）的影响。
（1）与主动呼吸相比，在被动呼吸时 CSA/Pph 在呼气时增加（11.7 ± 7.1 对 8.5 ± 5.6mm(2)/cmH(2)O；p < 0.05），但在吸气时没有增加。（2）NC 与被动呼气时的 CSA/Pph 相关（R(2) = 0.77，p < 0.05）。（3）NC 和 EELV 在主动和被动呼吸之间没有变化（p = NS）。
（1）抑制通气运动输出会增加咽腔顺应性。（2）增加的被动呼气咽腔顺应性与 NC 或 EELV 的变化无关。
