Aoyagi Toshiki, Shinohara Nobuo, Kubota-Chikai Kanako, Kuroda Naoto, Nonomura Katsuya
Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Urol Int. 2011;86(4):487-90. doi: 10.1159/000323866. Epub 2011 Feb 19.
Adult-onset Xp11.2 translocation renal cell carcinoma is a rare malignancy that has an aggressive clinical course and poor prognosis. The reasons for this include the fact that most patients have an advanced clinical stage at diagnosis and also that there is a lack of effective systemic therapy. We herein present the case of a 32-year-old woman suffering from node-positive Xp11.2 translocation renal cell carcinoma who underwent radical nephrectomy with an extensive retroperitoneal lymph node dissection, followed by two times of surgical resection for recurrent nodal disease. The patient has experienced no recurrent disease 4.5 years after the last operation and remains free of disease. Surgical approach to recurrent disease, if the recurrent site can be judged to be limited, might be one of the feasible treatment options in patients with Xp11.2 translocation renal cell carcinoma.
成人型Xp11.2易位性肾细胞癌是一种罕见的恶性肿瘤，临床病程侵袭性强，预后较差。其原因包括大多数患者在诊断时处于临床晚期，且缺乏有效的全身治疗。我们在此报告一例32岁患有淋巴结阳性Xp11.2易位性肾细胞癌的女性患者，该患者接受了根治性肾切除术及广泛的腹膜后淋巴结清扫术，随后因复发性淋巴结疾病进行了两次手术切除。患者在最后一次手术后4.5年未出现疾病复发，目前仍无疾病迹象。对于复发性疾病，如果复发部位可判断为局限，手术治疗可能是Xp11.2易位性肾细胞癌患者可行的治疗选择之一。
