Department of Neurology, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, Utrecht, The Netherlands.
Dement Geriatr Cogn Disord. 2011;31(2):152-7. doi: 10.1159/000324437. Epub 2011 Feb 18.
BACKGROUND/AIM: Cardiovascular risk factors play an important role in the development of cognitive impairment and dementia. We examined whether a previously designed dementia risk score based on midlife vascular risk profiles also predicts cognitive impairment 15 years later.
322 individuals without dementia from the population-based Hoorn study (aged 50-64 years) underwent a medical examination at baseline and a detailed cognitive assessment 15 years later. The relation between the risk score and late-life cognitive impairment in each of 6 domains was analyzed with logistic regression analysis.
The risk score was significantly related to impairment on the domains information-processing speed (p = 0.04), visuoconstruction (p = 0.04) and abstract reasoning (p = 0.02). Participants with a risk score of 9 points or more had a markedly increased risk of late-life impairment in the domains information-processing speed (OR 3.07, 95% CI 1.37-6.90; p = 0.007) and abstract reasoning (OR 3.97, 95% CI 1.07-14.71; p = 0.04).
A previously designed risk score for dementia also predicts late-life cognitive impairment. Because such impairment can lead to complaints and functional consequences, also in individuals who do not progress to dementia, identification of individuals at risk is important and can help to target preventive strategies.
背景/目的：心血管危险因素在认知障碍和痴呆的发展中起着重要作用。我们研究了基于中年血管风险概况设计的痴呆风险评分是否也可以预测 15 年后的认知障碍。
322 名来自人群为基础的霍恩研究（年龄在 50-64 岁）且没有痴呆的个体在基线时接受了体检，并在 15 年后进行了详细的认知评估。使用逻辑回归分析来分析风险评分与 6 个领域的晚年认知障碍之间的关系。
风险评分与信息处理速度（p = 0.04）、视觉构建（p = 0.04）和抽象推理（p = 0.02）领域的障碍显著相关。风险评分达到 9 分或更高的参与者在信息处理速度（OR 3.07，95%CI 1.37-6.90；p = 0.007）和抽象推理（OR 3.97，95%CI 1.07-14.71；p = 0.04）领域的晚年认知障碍的风险显著增加。
先前设计的痴呆风险评分也可以预测晚年认知障碍。由于这种障碍会导致抱怨和功能后果，即使在没有进展为痴呆的个体中也是如此，因此识别高危个体很重要，并且可以帮助确定预防策略。
