PDT Center, Shanghai Skin Diseases and STD Hospital, Shanghai, P R China.
Photochem Photobiol Sci. 2011 May;10(5):704-11. doi: 10.1039/c0pp00373e. Epub 2011 Feb 18.
In dermatology, photodynamic therapy (PDT) has become a well established treatment modality which has been shown to be effective and safe for many skin and mucosal disorders. Pre-clinical and clinical studies demonstrate that, in addition to the direct local cytotoxicity and vascular effects, PDT can induce various host immune responses. Recent clinical data also show that improved clinical outcomes can be obtained through the sequential use of PDT and immunomodulation. This article will provide an update on the current status of such a combination in dermatological applications.
在皮肤科领域，光动力疗法（PDT）已成为一种成熟的治疗方式，已被证明对许多皮肤和黏膜疾病有效且安全。临床前和临床研究表明，除了直接的局部细胞毒性和血管作用外，PDT 还可以诱导各种宿主免疫反应。最近的临床数据还表明，通过 PDT 和免疫调节的序贯使用可以获得更好的临床效果。本文将提供皮肤科应用中这种联合治疗的最新现状。
