Caugant D A
Department of Bacteriology, National Institute of Public Health, Oslo, Norway.
Methods Mol Med. 2001;67:273-92. doi: 10.1385/1-59259-149-3:273.
The unambiguous identification of epidemic Neisseria meningitidis strains and their clear distinction from other less pathogenic meningococci is required for the global epidemiology of meningococcal disease. Until the recent development of multi-locus sequence typing (1), multi-locus enzyme electrophoresis (abbreviated MEE or MLEE) was the only method to permit large-scale analysis of N. meningitidis strains causing disease in various parts of the world and to document the intercontinental spread of particularly pathogenic organisms (2-8).
为了开展全球范围的脑膜炎球菌病流行病学研究，需要对流行性脑膜炎奈瑟菌菌株进行明确鉴定，并将其与其他致病性较低的脑膜炎球菌清楚区分开来。在多位点序列分型方法（1）近期出现之前，多位点酶电泳法（缩写为MEE或MLEE）是唯一能够对世界各地引起疾病的脑膜炎奈瑟菌菌株进行大规模分析，并记录特定致病生物体洲际传播情况的方法（2-8）。
