Visser H A A H, Visser-van Leeuwen M, Huizer H
Netherlands Forensic Institute, The Hague, Netherlands.
Bull Narc. 2005;57(1-2):167-82.
Various solvents can be used in the synthesis of the illicit synthetic drug methylenedioxymethamphetamine (MDMA, commonly known as Ecstasy). In the crystallization process, traces of those solvents can be trapped inside crystals; during the following tabletting process, the solvent traces remain present in the tablets. The forensic investigation of tablets for solvents may increase knowledge of production methods and contribute to a possible choice of monitoring or regulating certain organic solvents. Further, the identification and quantification of solvents in MDMA tablets may contribute to the chemical characterization of illicit tablets for comparative examination. The methods of analysis of volatile components in illicit MDMA tablets described so far are often based on solid-phase micro extraction (SPME). To avoid several disadvantages of SPME, a quantitative static headspace method was developed using gas chromatography/mass spectrometry (GC/MS); for quantification, the standard addition method appeared to be advantageous. The residual solvents in 155 MDMA tablets were analysed and 150 of them were quantified.
多种溶剂可用于非法合成药物亚甲基二氧甲基苯丙胺（MDMA，俗称摇头丸）的合成。在结晶过程中，这些溶剂的痕量可能会被困在晶体内部；在随后的压片过程中，溶剂痕量仍会存在于片剂中。对片剂进行溶剂的法医调查可能会增加对生产方法的了解，并有助于选择监测或监管某些有机溶剂。此外，MDMA片剂中溶剂的鉴定和定量可能有助于对非法片剂进行化学表征以便进行比较检验。到目前为止所描述的非法MDMA片剂中挥发性成分的分析方法通常基于固相微萃取（SPME）。为避免SPME的几个缺点，开发了一种使用气相色谱/质谱联用（GC/MS）的定量静态顶空方法；对于定量分析，标准加入法似乎具有优势。对155片MDMA片剂中的残留溶剂进行了分析，其中150片进行了定量。
