National Research Council, Institute of Molecular Medicine, Rome, Italy.
Clin Chim Acta. 2011 May 12;412(11-12):1053-9. doi: 10.1016/j.cca.2011.02.020. Epub 2011 Feb 19.
There is still no study evaluating the influence of gestational age (GA) per se on C reactive protein (CRP) and procalcitonin (PCT) reference intervals. We therefore investigated how length of gestation, age (hours), and prenatal and perinatal variables might influence the levels of CRP and PCT. We also determined 95% age-specific reference intervals for CRP and PCT in healthy preterm and term babies during the early neonatal period.
One blood sample (one observation per neonate) was taken for CRP and PCT from each newborn between birth and the first 4 (for term), or 5 days (for preterm newborns) of life by using a high-sensitive CRP and PCT assays.
Independently of gender and sampling time, GA had a significantly positive effect on CRP, and a significantly negative effect on PCT. Compared with healthy term babies, healthy preterm babies had a lower and shorter CRP response, and, conversely, an earlier, higher, and longer PCT response. CRP reference intervals were affected by a number of pro-inflammatory risk factors.
Age- and GA-specific reference ranges for both CRP and PCT should be taken into account to optimize their use in the diagnosis of early-onset neonatal sepsis.
目前尚无研究评估胎龄（GA）本身对 C 反应蛋白（CRP）和降钙素原（PCT）参考区间的影响。因此，我们研究了妊娠时间、年龄（小时）以及产前和围产期变量如何影响 CRP 和 PCT 的水平。我们还确定了健康早产儿和足月儿在新生儿早期 CRP 和 PCT 的 95%年龄特异性参考区间。
使用高敏 CRP 和 PCT 检测方法，在新生儿出生后至第 4 天（足月儿）或第 5 天（早产儿）期间，对每个新生儿的每一个血液样本（每个新生儿一个观察值）进行 CRP 和 PCT 检测。
无论性别和采样时间如何，GA 对 CRP 均有显著的正影响，对 PCT 有显著的负影响。与健康足月儿相比，健康早产儿 CRP 反应较低且持续时间较短，而 PCT 反应则更早、更高且持续时间更长。CRP 参考区间受多种促炎风险因素的影响。
应考虑 CRP 和 PCT 的年龄和 GA 特异性参考范围，以优化其在早期新生儿败血症诊断中的应用。
