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[≥65岁患者中根据血压测量程序划分的动脉高血压控制程度差异。FAPRES研究]

[Differences in the degree of control of arterial hypertension according to the measurement procedure of blood pressure in patients ≥ 65 years. FAPRES study].

作者信息

Llisterri J L, Morillas P, Pallarés V, Fácila L, Sanchís C, Sánchez T

机构信息

Centro de Salud Joaquín Benlloch, Valencia, España.

出版信息

Rev Clin Esp. 2011 Feb;211(2):76-84. doi: 10.1016/j.rce.2010.11.005. Epub 2011 Feb 19.

DOI:10.1016/j.rce.2010.11.005
PMID:21338985
Abstract

BACKGROUND AND OBJECTIVES

Control of arterial blood pressure (BP) in hypertensive patients differs based on the evaluation procedure. This fact can be enhanced in subjects over 65 years of age. We have studied the degree of BP control with determinations in the office or ambulatory blood pressure monitoring (ABPM).

METHODS

A multicenter, cross-sectional study was conducted in primary care (PC) and hypertension units in the Valencian Community. The first three hypertensive patients ≥ 65 years who attended the consultation on the first day of visits of the week of each investigator were included in the study. Cardiovascular risk factors, target organ damage and associated cardiovascular disease were recorded. Good clinical control values were defined as < 140/90 in the office and < 130/80 by ABPM for 24-hour according to 2007 ESH/ESC guidelines.

RESULTS

A total of 1,028 hypertensive patients were included, 52.7% of whom were women, with a mean age of 72.6 years. Mean clinical BP was 146.7/81.1 mmHg and 24-hour ABPM 128.5/70.8 mmHg. Ninety-two percent of the patients were treated with antihypertensive drugs (35.6% monotherapy and 56.4% with combinations of two or more drugs). Good clinical control was found in 35.3% of cases (CI 95%: 32.4-38.2) and 50.9% (CI 95%: 47.8-54.0) (P < .001) had good control of 24-hour BP in ABPM. Male gender, personal background of heart disease and stroke were associated with good control of hypertension (P < .01) in 24-hour ABPM.

CONCLUSIONS

In hypertensive patients over 65 years, and compared to the clinical determination of BP, the evaluation of ABMP showed a better proportion of controlled subjects. These findings support a wider use of ABPM to evaluate the control of BP in this population.

摘要

背景与目的

高血压患者动脉血压(BP)的控制情况因评估方法而异。这一情况在65岁以上人群中更为明显。我们通过诊室测量或动态血压监测(ABPM)来研究血压控制程度。

方法

在巴伦西亚自治区的初级保健(PC)机构和高血压科室开展了一项多中心横断面研究。纳入研究的为每位研究者每周第一天就诊时前来咨询的前三位年龄≥65岁的高血压患者。记录心血管危险因素、靶器官损害及相关心血管疾病情况。根据2007年欧洲高血压学会/欧洲心脏病学会(ESH/ESC)指南,诊室血压良好控制值定义为<140/90 mmHg,ABPM 24小时血压良好控制值定义为<130/80 mmHg。

结果

共纳入1028例高血压患者,其中52.7%为女性,平均年龄72.6岁。平均诊室血压为146.7/81.1 mmHg,ABPM 24小时血压为128.5/70.8 mmHg。92%的患者接受了降压药物治疗(35.6%为单药治疗,56.4%为两种或更多药物联合治疗)。35.3%的病例达到良好临床控制(95%置信区间:32.4 - 38.2),50.9%(95%置信区间:47.8 - 54.0)在ABPM中24小时血压得到良好控制(P <.001)。男性、有心脏病和中风个人史与ABPM中24小时高血压良好控制相关(P <.01)。

结论

在65岁以上高血压患者中,与诊室血压测定相比,ABPM评估显示血压得到控制的患者比例更高。这些发现支持更广泛地使用ABPM来评估该人群的血压控制情况。

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