Department of Medical Oncology, Cancer Genomics Center, UMC Utrecht, The Netherlands.
Oncogene. 2011 Jun 23;30(25):2799-809. doi: 10.1038/onc.2011.30. Epub 2011 Feb 21.
Most of the current drugs used to treat cancer can be classified as anti-proliferative drugs. These drugs perturb the proliferative cycle of tumor cells at diverse stages of the cell cycle. Examples of such drugs are DNA-damaging agents and inhibitors of cyclin-dependent kinases that arrest cell cycle progression at different stages of interphase. Another class of anti-proliferative drugs is the so-called anti-mitotic drugs, which selectively perturb progression through mitosis. Mitosis is the shortest and final stage in the cell cycle and has evolved to accurately divide the duplicated genome over the two daughter cells. This review deals with the different strategies that are currently considered to perturb mitotic progression in the treatment of cancer.
目前用于治疗癌症的大多数药物可分为抗增殖药物。这些药物在细胞周期的不同阶段扰乱肿瘤细胞的增殖周期。此类药物的例子有破坏 DNA 的药物和细胞周期蛋白依赖性激酶抑制剂，它们可使细胞周期在有丝分裂的不同阶段停滞。另一类抗增殖药物是所谓的有丝分裂抑制剂，它们选择性地扰乱有丝分裂的进展。有丝分裂是细胞周期中最短和最后的阶段，其进化目的是准确地将复制的基因组分配到两个子细胞中。这篇综述讨论了目前被认为用于扰乱有丝分裂进展以治疗癌症的不同策略。
