Amaral Josalmir José Melo do, Pomerantzeff Pablo Maria Alberto, Casagrande Ivan Sergio Joviano, Cestari Idágene Aparecida, Gutierrez Paulo Sampaio, Stolf Noedir Groppo
Faculdade de Medicina, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
Rev Bras Cir Cardiovasc. 2010 Oct-Dec;25(4):543-51. doi: 10.1590/s0102-76382010000400019.
The necessity for replacement of the valve, ascending aorta and aortic with coronary reimplantation in patients where anti-coagulation is undesirable, is increasing. We evaluated the hemodynamic performance of an aortic valved conduit made with glutaraldehyde treated bovine pericardium (AVCP) in animals.
Therefore, AVCPs were implanted in eight young ovine and explanted after 150 days. Angiographic and hemodynamic study was performed at pre-operative and prior the explant. EchoDopplercardiograms were performed at day 30 and 150 of post-operative (test) and also in five nonoperated ovines. After explanted, AVCPs were submitted to a macroscopical, radiological and histological evaluation by optic microscopy.
In the hemodynamic analysis the arterial and pulmonary capillary pressure increased (P<0.05) between day 0 and 150. In the echoDoppercardiographic analysis, the test group presented higher values in the diastolic and systolic diameters of the left ventricle (P<0.05). In the test group, between day 30 and 150, occurred an increase of weight, thickness of the left ventricle walls, maximum transvalvar gradient, medium transvalvar gradient, left ventricle diastolic diameter and a decrease in the ejection function (P<0.05). Two animals with endocarditis explain those differences, how we can see with the statistical analysis without this sample. Macroscopy showed calcification in variable degrees. Optic microscopy revealed data similar to literature with the use of glutaraldehyde treated bovine pericadium.
These data indicate that the AVCPs allows the performance of this kind of experiment in the proposed model and that the hemodynamic outcomes found are similar to physiological parameters.
在不适合进行抗凝治疗的患者中，更换瓣膜、升主动脉和主动脉并进行冠状动脉再植入的必要性日益增加。我们评估了用戊二醛处理的牛心包制成的带主动脉瓣管道（AVCP）在动物中的血流动力学性能。
因此，将AVCP植入八只年轻绵羊体内，并在150天后取出。在术前和取出前进行血管造影和血流动力学研究。在术后第30天和150天（测试）以及五只未手术的绵羊中进行超声心动图检查。取出后，对AVCP进行宏观、放射学和光学显微镜组织学评估。
在血流动力学分析中，第0天至150天期间动脉和肺毛细血管压力升高（P<0.05）。在超声心动图分析中，测试组左心室舒张和收缩直径的值更高（P<0.05）。在测试组中，第30天至150天期间，体重、左心室壁厚度、最大跨瓣压差、平均跨瓣压差、左心室舒张直径增加，射血功能降低（P<0.05）。两只患有心内膜炎的动物解释了这些差异，正如我们在不包括该样本的统计分析中所看到的那样。宏观检查显示不同程度的钙化。光学显微镜显示的数据与使用戊二醛处理牛心包的文献相似。
这些数据表明，AVCP能够在所提出的模型中进行此类实验，并且所发现的血流动力学结果与生理参数相似。
