Yurdakul Ahmet Selim, Akyürek Nalan, Demirtaş Senay, Karakaya Jale, Memiş Leyla, Oztürk Can
Department of Chest Diseases, Faculty of Medicine, Gazi University, Ankara, Turkey.
Tuberk Toraks. 2010;58(4):351-6.
Poor prognosis in the lung cancer result from early metastatic potential of the tumoral cells. The mechanisms of tumoral cell metastasis are complex. Adhesion molecules play an important role in metastatic process, which is cell-to-cell and cell-to-matrix interactions and chemokins which arrange the migration and growth of the cells are also important in metastatic biology. The aim of this study is to investigate the prognostic relevance of carcinoembrionic antigen cell adhesion molecule 1 (CEACAM1) and chemokine receptor CXCR4 expression in patients with non-small cell lung cancer (NSCLC). Using immunohistochemical analysis, we evaluated CEACAM1 and CXCR4 expression in parafine specimens from 50 patients with NSCLC confirmed histopathologically and the relationship between CEACAM1 and CXCR4 expression and the prognosis. Twenty-one (42%) patients were positive and 29 (58%) were negative for CEACAM1 expression. Patients whose tumors had CEACAM1-positive staining had a shorter duration of survival than patients whose tumors had no expression, but it was not significant statistically [8.93 ± 8, (median: 8) vs 12.3 ± 11.3, (median: 9), p> 0.36]. Twenty-three (46%) patients were positive and 27 (54%) were negative for CXCR4 expression. Patients whose tumors had CXCR4-positive staining had a longer duration of survival than patients whose tumors had no expression, but it was not significant statistically [12.8 ± 12.4, (median: 12) vs 9.3 ± 7.6, (median: 8), p> 0.14]. In conclusion, CEACAM1 and CXCR4 played a part in metastatic process in lung cancer may not affect on survival independently. The biologic mechanisms leading to the spread of tumor cells are complex and related multifactoriel process.
肺癌预后不良源于肿瘤细胞早期的转移潜能。肿瘤细胞转移的机制复杂。黏附分子在转移过程中起重要作用，即细胞间和细胞与基质的相互作用，而调控细胞迁移和生长的趋化因子在转移生物学中也很重要。本研究的目的是调查癌胚抗原细胞黏附分子1（CEACAM1）和趋化因子受体CXCR4表达与非小细胞肺癌（NSCLC）患者预后的相关性。我们采用免疫组化分析方法，评估了50例经组织病理学确诊的NSCLC患者石蜡标本中CEACAM1和CXCR4的表达情况，以及CEACAM1和CXCR4表达与预后的关系。CEACAM1表达阳性的患者有21例（42%），阴性的有29例（58%）。肿瘤CEACAM1染色阳性的患者生存时间短于无表达的患者，但差异无统计学意义[8.93±8，（中位数：8）对12.3±11.3，（中位数：9），p>0.36]。CXCR4表达阳性的患者有23例（46%），阴性的有27例（54%）。肿瘤CXCR4染色阳性的患者生存时间长于无表达的患者，但差异无统计学意义[12.8±12.4，（中位数：12）对9.3±7.6，（中位数：8），p>0.14]。总之，CEACAM1和CXCR4在肺癌转移过程中发挥作用，但可能不独立影响生存。导致肿瘤细胞扩散的生物学机制复杂且是多因素相关过程。
