Ansseau M, Papart P, Gérard M A, von Frenckell R, Franck G
Psychiatric Unit, Centre Hospitalier Universitaire de Liège, Belgium.
Neuropsychobiology. 1990;24(2):74-8. doi: 10.1159/000119464.
The anxiolytic activity, the tolerance, and the withdrawal symptoms of buspirone and oxazepam were compared in two groups of 14 and 12 outpatients, respectively, suffering from generalized anxiety in a double-blind study with random allocation of patients. The 6-week active period was preceded and followed by 1 and 2 weeks on placebo, respectively. Clinical assessments were performed before and after the predrug placebo period and every 2 weeks thereafter and included Hamilton anxiety and depression scales and AMDP anxiety subscale. The initial daily dose was 15 mg buspirone or 45 mg oxazepam in 3 intakes and the mean final daily doses were 22.2 and 55.8 mg, respectively. Results showed a slower anxiolytic activity of buspirone compared to oxazepam with less improvement after 2 weeks of treatment. The rebound anxiety following abrupt discontinuation of the drug and the level of side effects did not significantly differ between the two compounds.
在一项双盲研究中，将两组分别为14名和12名的门诊患者随机分配，比较丁螺环酮和奥沙西泮的抗焦虑活性、耐受性及戒断症状，这些患者均患有广泛性焦虑症。在为期6周的活性治疗期之前和之后，分别有1周和2周的安慰剂治疗期。在用药前安慰剂期前后以及此后每2周进行临床评估，评估内容包括汉密尔顿焦虑和抑郁量表以及AMDP焦虑分量表。初始每日剂量为丁螺环酮15mg或奥沙西泮45mg，分3次服用，平均最终每日剂量分别为22.2mg和55.8mg。结果显示，与奥沙西泮相比，丁螺环酮的抗焦虑活性起效较慢，治疗2周后改善较少。两种药物突然停药后的反跳性焦虑以及副作用水平无显著差异。
