Bonforte Giuseppe, Pogliani Daniela, Genovesi Simonetta
U.O. Nefrologia e Dialisi, Ospedale Sant'Anna, Como, Italy.
G Ital Nefrol. 2011 Jan-Feb;28(1):48-56.
Arteriovenous fistula (AVF) surveillance is pivotal to early detection of stenosis, in order to avoid subsequent thrombosis. Access flow measurement is the method recommended by the available guidelines. With respect to grafts, in native AVF the best thresholds of access flow intervention, optimal timing of monitoring and cost-effectiveness are still debated. In fact, monthly measurement of access flow is difficult to obtain in most modern hemodialysis units. Moreover, in native AVF it is not always possible to perform the gold-standard surveillance methods. Finally, clinical evaluation is not enough to identify the small number of patients at risk of stenosis. The QB stress test (QBST) is a new and simple screening test that was created to identify inflow stenosis and thereby malfunctioning AVF. QBST shows a good correlation with access flow measurements obtained by the ultrasound dilution technique. Moreover, the test can be performed in every type of native AVF. Patients with a positive QBST result had a lower access flow than patients with a negative QBST result (433+-203 vs 1168+-681 mL/min, p<0.0001). The positive predictive value for inflow stenosis was 76.3%. During a 22-month followup, we were able to achieve a low thrombosis rate (1.5 instances of thrombosis per 100 patient-years). In conclusion, adding QBST to the clinical evaluation could offer a new solution for the long-standing AVF surveillance problem.
动静脉内瘘(AVF)监测对于早期发现狭窄至关重要,以便避免随后的血栓形成。通路血流量测量是现有指南推荐的方法。关于移植物,在自体动静脉内瘘中,通路血流量干预的最佳阈值、最佳监测时机和成本效益仍存在争议。事实上,在大多数现代血液透析单位,每月测量通路血流量很难实现。此外,在自体动静脉内瘘中,并不总是能够采用金标准监测方法。最后,临床评估不足以识别少数有狭窄风险的患者。QB压力测试(QBST)是一种新的简单筛查测试,旨在识别流入道狭窄,从而发现功能不良的动静脉内瘘。QBST与通过超声稀释技术获得的通路血流量测量结果具有良好的相关性。此外,该测试可在各种类型的自体动静脉内瘘中进行。QBST结果为阳性的患者的通路血流量低于QBST结果为阴性的患者(433±203 vs 1168±681 mL/分钟,p<0.0001)。流入道狭窄的阳性预测值为76.3%。在22个月的随访期间,我们能够实现较低的血栓形成率(每100患者年1.5次血栓形成事件)。总之,将QBST添加到临床评估中可为长期存在的动静脉内瘘监测问题提供新的解决方案。