Integrated Department of immunology, University of Colorado School of Medicine, National Jewish Health, Denver, CO 80206, USA.
Eur J Immunol. 2011 Mar;41(3):592-4. doi: 10.1002/eji.201141408. Epub 2011 Feb 11.
The recognition of lipid antigens by T cells is a complex and fascinating phenomenon. The MHC-like molecules of the CD1 family have evolved to present a wide variety of both self and foreign lipids for recognition by T-cell receptors. While much progress has been made in our understanding of the NKT cells that recognize lipids presented by CD1d molecules, our knowledge of the T-cell populations directed at the related group 1 CD1 molecules, i.e. CD1a, CD1b and CD1c, has lagged behind. In this issue of the European Journal of Immunology, a study identifies a surprisingly large portion of human peripheral blood T cells as being autoreactive to the group 1 CD1 proteins. This work and other recent developments highlight the presence of a substantial number of unconventional T cells as part of our normal T-cell repertoire. This interesting finding is discussed in details in this commentary.
T 细胞识别脂质抗原是一个复杂而迷人的现象。CD1 家族的 MHC 样分子进化为能够呈现各种自身和外来脂质，以供 T 细胞受体识别。尽管我们在理解识别 CD1d 分子呈现的脂质的 NKT 细胞方面已经取得了很大进展，但我们对针对相关的 CD1 分子群 1（即 CD1a、CD1b 和 CD1c）的 T 细胞群体的了解却落后了。在本期《欧洲免疫学杂志》上，一项研究确定了相当一部分人类外周血 T 细胞对 CD1 蛋白群 1 具有自身反应性。这项工作和其他最近的发展强调了大量非常规 T 细胞作为我们正常 T 细胞库的一部分的存在。在这篇评论中详细讨论了这一有趣的发现。
