Hashimoto M
Department of Pedodontics, Faculty of Dentistry, Tokyo Medical and Dental University.
Shoni Shikagaku Zasshi. 1990;28(4):956-67.
As Colchicine is an inhibitor of the function of microtubles, administration of it causes abnormal amelogenesis in the teeth of experimental animals. The purposes of this study were to characterize the defective rat enamel which was formed after a single administration of colchicine, and to examine the effects of Nd:YAG laser with continuous wave on the acid resistance of the defective enamel. The following results were obtained: 1) On about the 10th day after a single subcutaneous injection of colchicine with a dose of 1.5 mg/kg of body weight, the defective enamel was found on the incisor as white bands with rough surface. 2) The defective enamel had less resistance to the acid demineralization than that of normal enamel. 3) After irradiation of Nd:YAG laser with continuous wave, the defective enamel surface became smooth and the small defects on the enamel surface disappeared. 4) After irradiation of Nd:YAG laser, the resistant level of the defective enamel to the acid demineralization increased up to that of normal enamel. The results suggest that Nd:YAG laser irradiation on human teeth with hypomineralized enamel may be effective for the prevention of dental caries.
由于秋水仙碱是微管功能的抑制剂，给实验动物施用秋水仙碱会导致其牙齿釉质形成异常。本研究的目的是表征单次施用秋水仙碱后形成的大鼠釉质缺陷，并研究连续波Nd:YAG激光对缺陷釉质耐酸性的影响。获得了以下结果：1）在单次皮下注射剂量为1.5mg/kg体重的秋水仙碱后约第10天，在切牙上发现有缺陷的釉质呈白色带，表面粗糙。2）有缺陷的釉质比正常釉质对酸脱矿的抵抗力更弱。3）连续波Nd:YAG激光照射后，有缺陷的釉质表面变得光滑，釉质表面的小缺陷消失。4）Nd:YAG激光照射后，有缺陷的釉质对酸脱矿的抵抗水平提高到正常釉质的水平。结果表明，对釉质矿化不足的人牙进行Nd:YAG激光照射可能对预防龋齿有效。
