Krivosheev A B, Krivosheev B N, Poteriaeva E L, Parulikova L V, Mikhaĭlenko O I
Ter Arkh. 2010;82(10):65-70.
To study the specific features of porphyrin metabolic disturbances in cadmium poisoning.
The paper describes a patient who has developed clinical and biochemical syndromes of acute porphyrinopathy after exposure to cadmium-containing paint the vapors. The levels of delta-aminolevulinic acid, porphobilinogen, coproporphyrin, and uroporphyrin in urine and those of coproporphyrin and protoporphyrin in feces were measured. The concentrations of lead, cadmium, and copper were determined in whole blood and urine; selective screening of amino acids for hereditary metabolic diseases was made.
The clinical signs of acute porphyrinopathy developed in the patient mimicked those of acute porphyries known by the current classification. The biochemical syndrome more corresponded to lead poisoning. However, the blood and urinary lead levels were not greater than the normal values, but the blood showed a 4-fold increase in cadmium, which seemed to induce porphyrin dysmetabolism.
研究镉中毒时卟啉代谢紊乱的具体特征。
本文描述了一名患者，其在接触含镉涂料蒸气后出现了急性卟啉病的临床和生化综合征。检测了尿液中δ-氨基乙酰丙酸、卟胆原、粪卟啉和尿卟啉的水平，以及粪便中粪卟啉和原卟啉的水平。测定了全血和尿液中铅、镉和铜的浓度；对遗传性代谢疾病进行了氨基酸选择性筛查。
该患者出现的急性卟啉病临床症状与当前分类中已知的急性卟啉病相似。生化综合征更符合铅中毒。然而，血铅和尿铅水平不高于正常值，但血液中镉含量增加了4倍，这似乎诱发了卟啉代谢紊乱。
