Department of Chemistry and the Alan G. MacDiarmid NanoTech Institute, The University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080-3021, United States.
J Am Chem Soc. 2011 Mar 16;133(10):3492-7. doi: 10.1021/ja109328a. Epub 2011 Feb 22.
Nitric oxide (NO) is an endogenous diatomic molecule important in regulation of numerous physiological functions. The photorelease of NO in a controlled manner can potentially be used in photodynamic therapy (PDT). We present here a method to combine S-nitrosocysteine with TiO(2) nanotube-doped PbS quantum dots (PbS QDs) as a nitric oxide-releasing vehicle to promote production of singlet oxygen. The PbS QDs with a diameter ∼3.6 nm (PbS/TNTs) were attached to the TiO(2) nanotube by using a thiolactic acid linker. S-nitrosocysteine-decorated PbS/TiO(2) nanotubes were prepared by dipping PbS/TNTs in a cysteine solution followed by nitrosylation. The results suggest that this hybrid nanomaterial is capable of photoreleasing nitric oxide and producing singlet oxygen using near-IR light.
一氧化氮（NO）是一种内源性双原子分子，在调节许多生理功能方面具有重要作用。以可控的方式释放一氧化氮有可能用于光动力疗法（PDT）。我们在此提出一种将 S-亚硝基半胱氨酸与 TiO2 纳米管掺杂的 PbS 量子点（PbS QDs）结合作为一氧化氮释放载体以促进单线态氧产生的方法。直径约为 3.6nm 的 PbS QDs（PbS/TNTs）通过硫代乳酸连接剂附着在 TiO2 纳米管上。S-亚硝基半胱氨酸修饰的 PbS/TiO2 纳米管是通过将 PbS/TNTs 浸入半胱氨酸溶液中然后进行亚硝化制备的。结果表明，这种杂化纳米材料能够使用近红外光光解释放一氧化氮并产生单线态氧。
