Shi Haitang, Niu Meng, Tan Longfei, Liu Tianlong, Shao Haibo, Fu Changhui, Ren Xiangling, Ma Tengchuang, Ren Jun, Li Linlin, Liu Huiyu, Xu Ke, Wang Jianxin, Tang Fangqiong, Meng Xianwei
Laboratory of Controllable Preparation and Application of Nanomaterials , Center for Micro/nanomaterials and Technology , Technical Institute of Physics and Chemistry , Chinese Academy of Sciences , Beijing 100190 , People's Republic of China . Email:
University of Chinese Academy of Sciences , Beijing 100049 , People's Republic of China.
Chem Sci. 2015 Aug 1;6(8):5016-5026. doi: 10.1039/c5sc00781j. Epub 2015 May 29.
This study develops a simple hollow ZrO nanostructure as a carrier to encapsulate ionic liquid (IL), which integrates the CT imaging function of the ZrO shell and the microwave susceptibility function of the IL core. The simple nanostructure can be used as a multifunctional theranostic agent combining diagnostic and therapeutic modalities into one "package". Based on the microwave susceptibility properties, the tumor inhibiting ratio can be over 90% in mice models after one-time thermal therapy upon microwave irradiation. and imaging results prove the potential of CT imaging application for real-time monitoring of biodistribution and metabolic processes, and assessing therapeutic outcomes. To our best knowledge, our study is the first example to achieve CT imaging and microwave thermal therapy simultaneously through a simple nanostructure. We anticipate that the simple IL@ZrO nanostructure may build a useful platform for the clinical imaging guided therapy of tumors.
本研究开发了一种简单的空心ZrO纳米结构作为载体来封装离子液体（IL），其整合了ZrO壳的CT成像功能和IL核的微波敏感性功能。这种简单的纳米结构可作为一种多功能诊疗试剂，将诊断和治疗方式整合于一个“组件”中。基于微波敏感性特性，在小鼠模型中，经微波照射进行一次热疗后，肿瘤抑制率可达90%以上。成像结果证明了CT成像在实时监测生物分布和代谢过程以及评估治疗效果方面的应用潜力。据我们所知，我们的研究是首个通过简单纳米结构同时实现CT成像和微波热疗的实例。我们预计，这种简单的IL@ZrO纳米结构可能为肿瘤的临床成像引导治疗搭建一个有用的平台。
