Jeremić L A, Kobilarov N L, Petrović S D
Department of Organic Chemistry, Faculty of Technology and Metallurgy, University of Belgrade, Yugoslavia.
Rapid Commun Mass Spectrom. 1990 Dec;4(12):498-9. doi: 10.1002/rcm.1290041204.
Electron-ionization-induced mass spectra of N-monosubstituted 2-phenylacetamides were recorded and their fragmentation patterns were studied by metastable-ion analyses. Representative deuterated analogues of these compounds have also been synthesized and their mass spectra compared with those of the unlabelled parent compounds. The most typical fragmentation for N-alkyl-, N-isoalkyl- and N-cycloalkyl-2-phenylacetamides is cleavage of the bond alpha to the carbonyl function, resulting in an ion fragment of m/z 92, following the transfer of hydrogen and elimination of a corresponding ketene. The primary fragmentation process for N-aryl substituted 2-phenylacetamides is the loss of an aromatic hydrogen atom from the molecular ion. The other principal fragmentation processes observed with these compounds are discussed.
记录了N-单取代2-苯基乙酰胺的电子电离诱导质谱，并通过亚稳离子分析研究了它们的裂解模式。还合成了这些化合物的代表性氘代类似物，并将它们的质谱与未标记母体化合物的质谱进行了比较。N-烷基-、N-异烷基-和N-环烷基-2-苯基乙酰胺最典型的裂解是羰基官能团α位的键断裂，在氢转移和相应乙烯酮消除后，产生m/z 92的离子碎片。N-芳基取代的2-苯基乙酰胺的主要裂解过程是分子离子失去一个芳香氢原子。讨论了这些化合物观察到的其他主要裂解过程。
