Department of Dermatology, Ehime University Graduate School of Medicine, Ehime, Japan.
J Dermatol. 2011 Mar;38(3):222-8. doi: 10.1111/j.1346-8138.2010.01176.x.
Drug-induced hypersensitivity syndrome (DIHS) is caused by a limited number of specific drugs and is characterized by late onset, infectious mononucleosis-like symptoms, and herpesvirus 6 (HHV-6) reactivation. Recently, the involvement of herpes viruses other than HHV-6, such as Epstein-Barr virus and cytomegalovirus, has been reported. Many approaches have been used to analyze the pathological mechanism, and have revealed new aspects of DIHS. Here, we focused on three key recent findings regarding DIHS: (i) overlap between DIHS and Stevens-Johnson syndrome/toxic epidermal necrolysis; (ii) the relevance of Epstein-Barr virus in the development of infectious mononucleosis-like symptoms of DIHS; and (iii) roles of monomyeloid precursors increased in the blood and plasmacytoid dendritic cells increased in the lesion skin in HHV-6 reactivation.
药物诱导的超敏反应综合征（DIHS）由少数特定药物引起，其特征为迟发性、类传染性单核细胞增多症症状和疱疹病毒 6（HHV-6）再激活。最近，除 HHV-6 以外的疱疹病毒如 EBV 和巨细胞病毒的参与已被报道。许多方法已被用于分析病理机制，并揭示了 DIHS 的新方面。在这里，我们重点关注与 DIHS 相关的三个关键的最新发现：（i）DIHS 与史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症的重叠；（ii）EBV 在 DIHS 类传染性单核细胞增多症症状发展中的相关性；和（iii）血液中单核细胞前体增加和病变皮肤中浆细胞样树突状细胞增加在 HHV-6 再激活中的作用。
