Department of Dermatology, College of Medicine, Hallym University, Seoul, Korea.
J Dermatol. 2011 Mar;38(3):272-5. doi: 10.1111/j.1346-8138.2010.00921.x. Epub 2010 Dec 13.
Acetazolamide is a sulfonamide derivative and carbonic anhydrase inhibitor used to lower intraocular pressure in glaucomatous patients. Stevens-Johnson syndrome (SJS) toxic epidermal necrolysis (TEN) associated with acetazolamide treatment has been diagnosed in Japanese, Japanese-American and Indian patients. Herein, we report the second Korean case of SJS-TEN associated with acetazolamide treatment. The result of human leukocyte antigen (HLA) typing of our patient was positive for HLA-B59. According to recent research, HLA-B59 has been detected in SJS caused by metazolamide, which is analogous to acetazolamide. This suggests a possible relationship between genetic background and SJS-TEN-associated acetazolamide treatment. Theretofore, acetazolamide should be prescribed to Korean patients with the same discreet caution.
乙酰唑胺是一种磺胺类衍生物和碳酸酐酶抑制剂，用于降低青光眼患者的眼内压。日本、日裔美国人和印度患者的乙酰唑胺治疗相关的史蒂文斯-约翰逊综合征（SJS）中毒性表皮坏死松解症（TEN）已被诊断。在此，我们报告了第二例与乙酰唑胺治疗相关的韩国 SJS-TEN 病例。我们患者的人类白细胞抗原（HLA）分型结果为 HLA-B59 阳性。根据最近的研究，HLA-B59 已在甲唑胺引起的 SJS 中被检测到，而甲唑胺与乙酰唑胺类似。这表明遗传背景与乙酰唑胺治疗相关的 SJS-TEN 之间可能存在一定关系。因此，乙酰唑胺在韩国患者中的使用应谨慎。
