Dr. Rasiklal Shah Sarvajanik Hospital, Modasa 383315, India.
Indian J Dermatol Venereol Leprol. 2009 Nov-Dec;75(6):579-82. doi: 10.4103/0378-6323.57718.
Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis are severe cutaneous reactions caused by certain drugs, including antiepileptic carbamazepine. A strong association has been reported between human leucocyte antigen (HLA)-B1502 and carbamazepine-induced SJS in Han Chinese patients. European studies suggested that HLA-B1502 is not a universal marker but is ethnicity-specific for Asians.
To study the association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.
Eight individuals who fulfilled the diagnostic criteria of SJS induced by carbamazepine were identified and HLA-B molecular typing was performed. HLA-B genotyping was carried out by polymerase chain reaction using sequence-specific primers.
Out of eight patients studied for genotype, six patients were found to have the HLA-B*1502 allele.
This study suggests an association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.
史蒂文斯-约翰逊综合征（SJS）和中毒性表皮坏死松解症是由某些药物引起的严重皮肤反应，包括抗癫痫药卡马西平。已报道人类白细胞抗原（HLA）-B1502 与汉族患者的卡马西平诱导 SJS 之间存在强烈关联。欧洲的研究表明，HLA-B1502 不是普遍的标志物，而是亚洲人种特异性的。
研究 HLA-B*1502 与印度患者卡马西平诱导 SJS 之间的关联。
鉴定了 8 名符合卡马西平诱导 SJS 诊断标准的个体，并进行了 HLA-B 分子分型。采用聚合酶链反应序列特异性引物进行 HLA-B 基因分型。
在研究的 8 名患者中，有 6 名患者存在 HLA-B*1502 等位基因。
本研究提示 HLA-B*1502 与印度患者卡马西平诱导 SJS 之间存在关联。
