Department of Oral Mucosal Diseases, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
J Oral Pathol Med. 2011 Apr;40(4):312-6. doi: 10.1111/j.1600-0714.2011.01016.x. Epub 2011 Feb 22.
Oral verrucous leukoplakia (VL) is one of the non-homogenous oral leukoplakias. The objective of this study was to investigate the clinicopathologic features of VL and identify the clinicopathologic risk factors that might be associated with VL malignant transformation from China.
Among 1541 patients with oral leukoplakia, a total of 53 patients with clinical and histopathologic diagnosis of VL between 1996 and 2009 were reviewed retrospectively in our hospital.
Of the 53 patients, 11 (20.8%) with VL were observed to develop cancer in the study period. The average age at diagnosis was 59.8 years with a male/female ratio of 1.7:1. Tongue was the predominant site (41.5%). Multivariate regression analysis revealed that the elderly patients (>65 years old) were associated with 8.36-fold [95% confidence interval (95% CI), 1.45-48.09; P = 0.017] increased risk of malignant transformation compared with the non-elderly patients. The lesion located on gingiva was associated with 20.81-fold (95% CI, 1.94-222.80; P = 0.012) increased risk of malignant transformation compared with tongue. However, the gender, smoking, alcohol intake, and epithelial dysplasia were not risk factors.
Clinicopathologic features of VL in China were elucidated. The utilization of age and lesion site at diagnosis as significant factors for evaluating malignant transformation risk in patients with VL was suggested. Further studies are required to investigate the roles of the potential risk factors in the VL malignant transformation.
口腔疣状白斑（VL）是一种非均质口腔白斑病。本研究旨在探讨 VL 的临床病理特征，并确定可能与中国 VL 恶性转化相关的临床病理危险因素。
在 1541 例口腔白斑患者中，回顾性分析了我院 1996 年至 2009 年间经临床和组织病理学诊断为 VL 的 53 例患者的资料。
在研究期间，观察到 53 例 VL 患者中有 11 例（20.8%）发生癌症。诊断时的平均年龄为 59.8 岁，男女比例为 1.7:1。舌是最常见的发病部位（41.5%）。多因素回归分析显示，与非老年患者相比，老年（>65 岁）患者发生恶性转化的风险增加 8.36 倍（95%可信区间[95%CI]，1.45-48.09；P=0.017）。与舌相比，病变位于牙龈的患者发生恶性转化的风险增加 20.81 倍（95%CI，1.94-222.80；P=0.012）。然而，性别、吸烟、饮酒和上皮不典型增生不是危险因素。
阐述了中国 VL 的临床病理特征。建议将年龄和诊断时的病变部位作为评估 VL 患者恶性转化风险的重要因素。需要进一步研究以探讨潜在危险因素在 VL 恶性转化中的作用。
