Schepman K P, van der Meij E H, Smeele L E, van der Waal I
Department of Oral and Maxillofacial Surgery and Pathology, Academic Hospital Vrije Universiteit/Academic Centre for Dentistry Amsterdam (ACTA), The Netherlands.
Oral Oncol. 1998 Jul;34(4):270-5.
A follow-up study of a hospital-based population of 166 patients with oral leukoplakia revealed a 2.9% annual malignant transformation rate. The median follow-up period was 29 months. Parameters associated with an increased risk of malignant transformation were female gender (P < 0.025), absence of smoking habits in women (P < 0.05), and a non-homogeneous clinical aspect (P = 0.01). For uniform reporting, a recently proposed classification and staging system has been used. Leukoplakias in stage IV, consisting of lesions with moderate or severe epithelial dysplasia, were associated with an increased risk of malignant transformation (P < 0.01). There were no oral subsites associated with an increased risk. Patients who had any form of intervention did not have a statistically significantly lower chance for malignant transformation than patients who were kept under surveillance without intervention.
一项针对166例口腔白斑患者的医院人群随访研究显示，年恶变率为2.9%。中位随访期为29个月。与恶变风险增加相关的参数包括女性性别（P<0.025）、女性无吸烟习惯（P<0.05）以及临床外观不均匀（P=0.01）。为了统一报告，采用了最近提出的分类和分期系统。IV期白斑，即伴有中度或重度上皮发育异常的病变，与恶变风险增加相关（P<0.01）。没有发现与恶变风险增加相关的口腔亚部位。接受任何形式干预的患者与未接受干预而接受监测的患者相比，恶变几率在统计学上没有显著降低。
