Santos José C H, Zhang Linjie, Menegatti Paula K, Guasselli Camila S, Celso Filho C M, Maito Lina R D M, Ferreira Marina F, Mariani Monallisa C, Wainwright Claire
Faculty of Medicine, Postgraduate Program on Health, Federal University of Rio Grande, Rio Grande, Brazil.
Pediatr Int. 2011 Aug;53(4):576-80. doi: 10.1111/j.1442-200X.2011.03333.x.
The relationship between viral bronchiolitis in early infancy and subsequent wheezing and asthma has been well established. The aim of the present cross-sectional study was to test the hypothesis that pneumonia severe enough to require hospitalization during the first 2 years of life could also be associated with asthma or asthma-like symptoms in pre-school children.
Structured interviews were conducted with parents of children who were classified as exposed (n= 36) or non-exposed (n= 84), based on whether they were hospitalized with radiologically confirmed pneumonia during the first 2 years of life. The main outcomes were ever physician-diagnosed asthma, asthma-like symptoms and use of anti-asthmatic medications during the last 2 months and during the last 12 months.
The prevalence of ever physician-diagnosed asthma was higher in the exposed group compared with the non-exposed group (41.6% vs 22.6%, P= 0.01), with an adjusted prevalence ratio of 2.03 (95% confidence interval: 1.10-3.62). The exposed group had a trend toward a higher prevalence of asthma-like symptoms and use of anti-asthmatic medications during the last 2 months and during the last 12 months.
Radiologically confirmed pneumonia in the first 2 years of life may be associated with asthma or asthma-like symptoms in pre-school children.
婴幼儿期的病毒性细支气管炎与随后的喘息及哮喘之间的关系已得到充分证实。本横断面研究的目的是检验以下假设：在生命的头两年中严重到需要住院治疗的肺炎，也可能与学龄前儿童的哮喘或哮喘样症状有关。
对儿童的父母进行结构化访谈，这些儿童根据在生命的头两年中是否因经放射学确诊的肺炎住院而分为暴露组（n = 36）或非暴露组（n = 84）。主要结局是曾被医生诊断为哮喘、哮喘样症状以及在过去2个月和过去12个月中使用抗哮喘药物的情况。
暴露组中曾被医生诊断为哮喘的患病率高于非暴露组（41.6% 对22.6%，P = 0.01），调整后的患病率比为2.03（95% 置信区间：1.10 - 3.62）。在过去2个月和过去12个月中，暴露组哮喘样症状的患病率及使用抗哮喘药物的比例有升高趋势。
生命头两年经放射学确诊的肺炎可能与学龄前儿童的哮喘或哮喘样症状有关。
