糖尿病临床标志物的研究。6. 红细胞山梨醇与糖尿病并发症
Studies on clinical markers of diabetes mellitus. 6. Red blood cell sorbitol and diabetic complications.
作者信息
Hatano M, Katsu K, Fuda H, Taguchi H, Aro T, Hiyoshi S, Sugiura M, Maruyama S
机构信息
Department of Internal Medicine, Meikai University School of Dentistry, Saitama, Japan.
出版信息
Meikai Daigaku Shigaku Zasshi. 1990;19(2):230-3.
The relationship between red blood cell sorbitol content and diabetic complications (cataract, retinopathy, neuropathy, and nephropathy) was examined in 23 non-insulin-dependent diabetic (NIDD) patients. Sorbitol content was abnormally high in 21 cases out of 23 NIDD patients. Sorbitol content in the non-neuropathy group and neuropathy group was 47.3 +/- 11.9 and 59.6 +/- 23.6 nmol/gHb, respectively. In the non-cataract group and cataract group, it was 49.0 +/- 17.6 and 66.0 +/- 23.5 nmol/gHb, respectively. The contents in the Scott I group and Scott II + III group were 54.9 +/- 20.7 and 58.7 +/- 24.0 nmol/gHb, respectively. Sorbitol content in the non-nephropathy group and nephropathy group was 52.8 +/- 19.8 and 61.1 +/- 21.9 nmol/gHb, respectively. The possibility that glyceraldehyde reductase (GAR) and sorbitol dehydrogenase (SDH) levels in red blood cells are also useful indicators of the presence of diabetic complications is strongly suggested.
对23例非胰岛素依赖型糖尿病（NIDD）患者的红细胞山梨醇含量与糖尿病并发症（白内障、视网膜病变、神经病变和肾病）之间的关系进行了研究。23例NIDD患者中有21例的山梨醇含量异常高。非神经病变组和神经病变组的山梨醇含量分别为47.3±11.9和59.6±23.6 nmol/gHb。非白内障组和白内障组的山梨醇含量分别为49.0±17.6和66.0±23.5 nmol/gHb。Scott I组和Scott II + III组的山梨醇含量分别为54.9±20.7和58.7±24.0 nmol/gHb。非肾病组和肾病组的山梨醇含量分别为52.8±19.8和61.1±21.9 nmol/gHb。强烈提示红细胞中的甘油醛还原酶（GAR）和山梨醇脱氢酶（SDH）水平也可能是糖尿病并发症存在的有用指标。
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